Assuming 50K investment avail to author content for a new site, what topic would you focus on?

I'm interested, would appreciate, finding out peoples' opinions/ takes on the following:
Assuming one had 100K available to build a new website--50K for original content and remainder for site setup/ marketing/ updating content/ working capital until business supports itself-- and wanted to create a 100% digital download/ publishing or similar website, with good prospects of eventually becoming automated to the extent the the owner can oversee it with less than 5 hours per week, what would you do?
Assume also for a moment that your hobbies and passions don't line up well with income producing niches, or that you simply aren't interested in trying to monetize them. Your content is going to be solely based on what you feel has the greatest chance of successfully reaching your goal.
Owner would work it full-time until sales reached a level where it was possible to delegate most site functions to others.

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